Why car sales are still falling sharply

Meanwhile, many of the pandemic’s hard-hit sectors – such as restaurants and travel – have seen robust recovery, with sales supported by the easing of public health restrictions and pent-up consumer demand. That’s not the case for car dealers, who are still waiting for their breakout moment. According to DesRosiers Automotive Consultants, approximately 130,000 light … Read more

Clinical study to investigate new tools to improve psychological treatment of adolescents with depression

Some studies have shown an alarming number of young people suffering from symptoms of depression. “We are talking about numbers reaching up to 60-80% of young people, including those with mild symptoms. And the numbers have probably increased with the pandemic,” explains Adrián Montesano, a researcher and member of the Faculty of Science. Psychology and … Read more

A new drug seeks ‘real revenge’ on COVID by turning the virus against itself

A neurologist at a prestigious US research institute has developed an experimental COVID treatment he calls “true revenge” that weapons the virus against itself. The treatment, called NMT5, was created by Dr. Stuart Lipton, the founder of the Neurodegeneration New Medicines Center at the Scripps Research Institute, and a team of scientists. It’s a derivative … Read more

Omicron reduces host antibody response due to lower B cell antigenicity

Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), numerous viral variants have emerged. These variants have shown improved transmissibility, virulence and immune evasion capacity. The most recent of these variants of concern (VOCs) detected is the Omicron B.1.1.529 variant, which contains the most … Read more

A case for updating COVID vaccines with beta variant spike sequences

To date, COVID-19 vaccines have been designed to protect against the ancestral strain of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recently, health authorities have advised changes to the design of the COVID-19 vaccine, i.e. replacement of the ancestral strain with other strains, to more efficiently fight the emerging SARS-CoV-2 variants. The main goal is to … Read more

COVID-19 vaccination provides sustained and potent neutralizing protection against variants compared to natural infection

In a recent study posted to the medRxiv* preprint server, investigators assessed immunoglobulin (Ig)-G responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after natural infection or vaccination. Study: Binding and neutralizing IgG responses to SARS-CoV-2 after natural infection or vaccination. Image credit: Fotomay/Shutterstock The widespread use of vaccination has been encouraged during the 2019 … Read more

The best scientific guidance lost the battle early during the COVID-19 pandemic

In a recent study published in Scientific progressresearchers used a mathematical model to represent how the general public drifted away from the best scientific guidance early during the 2019 coronavirus disease (COVID-19) pandemic. Study: Losing the battle for the best scientific guidance at an early stage of a crisis: COVID-19 and beyond. Image credit: View … Read more

Broad neutralizing antibodies are the blueprint for variant-resistant pansarbecovirus vaccines

A recent Nature Reviews Immunology study summarized the efficacy of neutralizing antibodies targeting four main regions of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), namely the receptor binding domain (RBD) in the S1 subunit , the fusion peptide region in the S2 subunit, the stem helix region and the N-terminal … Read more

Why Canadians in Need of Money Could Go Bankrupt Soon

“Ridiculously high.” That’s how Doug Hoyes describes the amount of debt Canadians carry. And he would know: The licensed insolvency manager spends his days working with people who are drowning in debt, at a time when consumer bankruptcy is at its highest level since the start of the pandemic. Interest rates are rising, a recession … Read more

Monkeypox virus structural analysis to guide broad antiviral drug development

In a recent study posted to the bioRxiv* preprint server, researchers investigated the crystalline structure of monkeypox (MPX) virus (MPXV) and the complex of VP39, a 2′-O-RNA methyltransferase (MTase) and sinefungin, a pan-MTase inhibitor. Study: The structure of the monkeypox virus 2′-O-ribose methyltransferase VP39 in complex with sinefungin provides the basis for the design of … Read more