New technologies and recent advances in the study of T cells and T cell epitope discovery in food allergy research

Although food allergies have been widespread for many years, their incidence has recently increased. In a recent study, scientists reviewed the latest technological advancements and the discovery of T cell epitope associated with food allergy. This review is available in the Journal of Allergy and Clinical Immunology. Study: Discovery of T cell epitope and single … Read more

Memory B and T cell responses differ when induced by SARS-CoV-2 infections or booster vaccinations

In a recent study published in The Journal of Immunology, a team of researchers from Japan examined the memory B and T cell responses to the spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after the booster dose of the 2019 coronavirus disease (COVID-19) messenger ribonucleic acid (mRNA) vaccine BNT162b2. They also … Read more

Approved and development of passive and active immunizations against respiratory syncytial virus in childhood and pregnancy

In a recent study published in Journal of Pediatricsresearchers investigated active and passive childhood vaccination against respiratory syncytial virus (RSV). Study: Current strategies and perspectives for active and passive immunization against respiratory syncytial virus in childhood. Image credit: ART-ur/Shutterstock Background Despite the global importance of RSV infections in children, only one monoclonal antibody, Palivizumab, has … Read more

Research findings may bolster the effectiveness of immune checkpoint therapy

Immune checkpoint inhibitors like Keytruda and Opdivo work by unleashing the immune system’s T cells to attack tumor cells. Their introduction ten years ago represented a major advancement in cancer therapy, but only 10% to 30% of treated patients experience long-term improvement. In an article published online today in The Journal of Clinical Research (JCI), … Read more

Following the road to immunity, cell by cell

Vaccines work their magic by effectively creating immune cells that last for a long time, often decades. These immune cells create both a protective barrier that can prevent or minimize reinfection and a memory that allows us to recognize and kill an old invader such as a virus before it causes disease. The antibody in … Read more

Exploring how pain can play a direct protective role in the gut

Can you introduce yourself and tell us about your background and what inspired you to conduct your latest research? Isaac Chiu, Ph.D. – I am an associate professor at Harvard Medical School in the Department of Immunology. I have my Ph.D. in immunology from Harvard University and my postgraduate training in the neurobiology of pain … Read more

Common Stomach Disease May Help Cause Crohn’s Disease, Study Suggests

An illustration of norovirus particles. Illustration: Shutterstock (Shutterstock) A nasty but short-lived stomach flu can have lasting consequences for a few unlucky ones. Researchers have found evidence in mice and human cells that infection with norovirus can cause Crohn’s disease in people who are already genetically predisposed to it. The findings may also help scientists … Read more

covid: How COVID detects damage to the heart could lead to new treatments

Researchers have discovered how COVID-19 infection damages heart tissue, paving the way for better treatments for the condition. The study in a small group of people found that COVID-19 damaged DNA in heart tissue, which was not detected in flu samples. The researchers noted that while COVID-19 and flu are both serious respiratory viruses, they … Read more

Broad neutralizing antibodies are the blueprint for variant-resistant pansarbecovirus vaccines

A recent Nature Reviews Immunology study summarized the efficacy of neutralizing antibodies targeting four main regions of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), namely the receptor binding domain (RBD) in the S1 subunit , the fusion peptide region in the S2 subunit, the stem helix region and the N-terminal … Read more

Tumors generate unique, temporary cell-in-cell structures to evade immunotherapy

Scientists have shown how tumor cells evade immune therapy by generating unique, temporary cell-in-cell structures, leaving the inner cells intact and able to revert to individual tumor cells. These findings, published today in eLife, provide a new theory of how tumor cells avoid destruction by the immune system. They may also inform the development of … Read more