Nanoparticles displaying SARS-CoV-1 and SARS-CoV-2 peaks induce broad antibody responses in animal models

A recent study published in the journal iScience reported that nanoparticles (NPs) displaying spike proteins from different sarbecoviruses together enhance the breadth of neutralizing reactions. Coronavirus disease 2019 (COVID-19) vaccines are based on the spike protein of the Wuhan-Hu-1 strain, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Mutant variants of SARS-CoV-2 are less sensitive … Read more

Myocarditis after COVID vaccination is rare, but more common in younger men

In a recent study published in the Journal of the Canadian Medical Association, researchers observed the incidence of myocarditis after messenger ribonucleic acid (mRNA)-based vaccination against coronavirus disease 2019 (COVID-19). In addition, they compared their estimates to expected rates based on the historical rates assessed before the COVID-19 vaccine rollout in British Columbia (BC), Canada. … Read more

Approved and development of passive and active immunizations against respiratory syncytial virus in childhood and pregnancy

In a recent study published in Journal of Pediatricsresearchers investigated active and passive childhood vaccination against respiratory syncytial virus (RSV). Study: Current strategies and perspectives for active and passive immunization against respiratory syncytial virus in childhood. Image credit: ART-ur/Shutterstock Background Despite the global importance of RSV infections in children, only one monoclonal antibody, Palivizumab, has … Read more

What is the role of adenoviruses in human health?

With advances in molecular biology informing recent advances in vaccinology, gene therapy, and other fields of medicine, human adenoviruses (HAdVs) have been of primary importance in medical research. A recent review in Trends in Molecular Medicine looks at the promises of HAdVs, their potential dangers and future challenges. Study: Adenoviruses in medicine: harmless pathogen, predator … Read more

SpyCatcher-SpyTag Technology Used to Develop Recombinant Protein-Based Intranasal Vaccine Against SARS-CoV-2

The findings of a new study posted to the bioRxiv* preprint server showed that the intranasal SpyCage vaccine platform may be protective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and may prove a versatile and adaptable modality for the formulation of intranasal vaccines targeting respiratory pathogens. Study: Intranasal virus-particle mimetic vaccine improves clearance of … Read more

Following the road to immunity, cell by cell

Vaccines work their magic by effectively creating immune cells that last for a long time, often decades. These immune cells create both a protective barrier that can prevent or minimize reinfection and a memory that allows us to recognize and kill an old invader such as a virus before it causes disease. The antibody in … Read more

Study highlights importance of flu vaccination

An international team of researchers has found that among patients hospitalized for flu, those who had been vaccinated had less severe infections, including the chance of children requiring hospitalization in an intensive care unit reduced by nearly half. In addition, the researchers found that deaths among hospitalized adults aged 65 or older who had been … Read more

Opportunities for improving seasonal vaccination strategy

Mitchell Rothholz, RPh, MBA: Any final suggestions or advice for our participants as they get ready to head into flu season? What are your pearls of wisdom? Randy McDonough, PharmD, MS, BCGP, BCPS, FAPhA: From my perspective, make every encounter with a patient count. When that patient is in front of you, make sure you … Read more

COVID-19 vaccination provides sustained and potent neutralizing protection against variants compared to natural infection

In a recent study posted to the medRxiv* preprint server, investigators assessed immunoglobulin (Ig)-G responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after natural infection or vaccination. Study: Binding and neutralizing IgG responses to SARS-CoV-2 after natural infection or vaccination. Image credit: Fotomay/Shutterstock The widespread use of vaccination has been encouraged during the 2019 … Read more

The potential for measles and rubella elimination worldwide

In a recent study published in The Lancet Global Healthresearchers have modeled the probability of eradication of measles and rubella by 2100. Study: Feasibility of measles and rubella vaccination programs for disease elimination: a pilot study. Image Credit: Design_Cells/Shutterstock Background The global increase in measles and rubella vaccination coverage has significantly reduced the infection pressure … Read more