Gut microbial flavonoid catabolite reverses fatty liver disease in mice

In a recent study published in the Procedures of the National Academy of Sciences (PNAS), researchers report that a microbial catabolite in the gut could reduce cardiometabolic disease (CMD) burden in mice. Study: A gut microbial metabolite of dietary polyphenols reverses obesity-induced fatty liver disease. Image credit: SvetaZi / Background Flavonoids exhibit anti-obesogenic, chemoprotective … Read more

Does Breastmilk Affect Babies’ Gut Microbiota?

A host of health-related benefits of probiotics have led to the development of a new discipline called probiogenomics, which focuses on the molecular mechanisms of probiotic activities. According to the U.S. Food and Drug Administration (FDA), next-generation probiotics meet the scope of “living biotherapeutic products” (LBPs), which can be used to develop effective therapies for … Read more

Glycan signatures in rheumatic diseases and their associated functional implications

The addition of sugars to a protein structure can influence the stability of the protein, interactions of receptors with ligands and activity of signaling pathways. This modification, called glycosylation, is linked to inflammation and disease progression. A new paper explores the understanding of glycosylation in a range of rheumatic diseases and indicates the potential for … Read more

Are Nasal Spray Vaccines the Solution to Respiratory Infectious Diseases?

A recent study published in the journal Trends in molecular medicine reviewed current efforts in developing nasal vaccines, delivery systems, and clinical applications for the prevention of respiratory disease. Review: Nasal Vaccines: Solutions to Respiratory Infectious Diseases. Image credit: Josep Suria / Shutterstock Introduction Mucosal surfaces are exposed to external environments and serve as primary … Read more

Memory B and T cell responses differ when induced by SARS-CoV-2 infections or booster vaccinations

In a recent study published in The Journal of Immunology, a team of researchers from Japan examined the memory B and T cell responses to the spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after the booster dose of the 2019 coronavirus disease (COVID-19) messenger ribonucleic acid (mRNA) vaccine BNT162b2. They also … Read more

Nanoparticles displaying SARS-CoV-1 and SARS-CoV-2 peaks induce broad antibody responses in animal models

A recent study published in the journal iScience reported that nanoparticles (NPs) displaying spike proteins from different sarbecoviruses together enhance the breadth of neutralizing reactions. Coronavirus disease 2019 (COVID-19) vaccines are based on the spike protein of the Wuhan-Hu-1 strain, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Mutant variants of SARS-CoV-2 are less sensitive … Read more

Klotho protein levels protect against cognitive decline in Alzheimer’s patients

In a recent JAMA network opened study, researchers compare Klotho protein levels in both cerebrospinal fluid (CSF) and plasma samples from healthy individuals and patients with different stages of Alzheimer’s disease (AD). Study: Association of klotho protein levels and KL-vs heterozygosity with Alzheimer’s disease and amyloid and tau burden. Image credit: ART-ur / Background … Read more

The relationship between neutralization levels and observed efficacy against asymptomatic and symptomatic infection of ten COVID-19 vaccines

In a recent study published on the medRxiv* server, researchers determined whether levels of neutralizing antibodies (NAb) were predictive of the efficacy of fractional vaccine doses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Study: Predictive efficacy of vaccine dose fractionation using neutralizing antibody levels. Image credit: Background During the 2016 yellow fever … Read more

Research reveals the existence of a hidden ”pocket” on the surface of the main SARS-CoV-2 protein

With the continued emergence of new variants and the risk of new virus strains, the development of innovative therapies against SARS-CoV-2 remains a major public health challenge. Currently, the proteins located on the surface of the virus and/or involved in its replication are the preferred therapeutic targets, such as the Spike protein targeted by vaccines. … Read more

MYC proteins form hollow spheres that shield the genome of cancer cells

MYC genes and their proteins play a central role in the onset and development of nearly all cancers. They stimulate the uncontrolled growth and altered metabolism of tumor cells. And they help tumors hide from the immune system. MYC proteins also show an activity that was previously unknown – and which is now opening new … Read more